Pioneering a new class of therapeutics designed to activate progenitor cells

Progenitor cells are similar to stem cells but are programmed to create specific cell types. These cells remain active and regenerate in some organs and tissues while becoming dormant in others.

Frequency was founded in 2014 based on research by Professors Robert S. Langer at the Massachusetts Institute of Technology and Jeffrey Karp at Harvard Medical School. Their work focused on ways to activate the body’s regenerative potential, building on the insight that continuously activated progenitor cells in the gut regenerate the human intestine every few days.

Studying this biological process, they identified signals that trigger the growth of new functional tissues and cells. Recognizing that similar progenitor cells were present but inactive in other organs, such as the cochlea within the ear, Professors Langer and Karp discovered how to adapt these natural signals using small molecules to temporarily activate progenitor cells to create a localized hearing response.

The Origins of Our Science

Advantages to our approach

Today, Frequency is pioneering a new class of small-molecule therapeutics designed to activate progenitor cells already present within the body to create healthy functional tissues and organs.

Our small molecule combinations are designed to induce a progenitor cell to temporarily enter an active state, replacing itself and regenerating a desired cell type.

We believe our PCA approach bypasses many challenges presented by cell and gene therapies and represents a transformative step in the evolution of regenerative medicine, reducing complexity by using small molecule therapeutics to temporarily reactivate progenitor cells that are already located at the tissue target site within the body and are pre-programmed to make specific cell types.

Activation of progenitor cells in the right location

  • Avoids the major challenge of delivering and integrating cells into the proper location within an organ
  • Activates the body’s own progenitor cells at the desired location in targeted tissues

Ease of manufacturing

  • Eliminates need to remove and grow live cells ex vivo
  • Produces treatments using standard, small-molecule manufacturing methods

Avoids permanent genetic changes

  • No need to alter genes
  • Small molecules designed to temporarily activate the native genes
  • Avoid risk of acquiring immune reactivity to our therapeutics

Our Therapeutic Discovery Process

Using combinations of small molecules to activate progenitor cells

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Our Pipeline and Programs

Working to reverse or repair damage caused by degenerative disease

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